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Michael Benatar Selected Research

Biomarkers (Surrogate Marker)

12/2023Biomarker Qualification for Neurofilament Light Chain in ALS: Theory and Practice.
1/2023Neurofilament light chain in drug development for amyotrophic lateral sclerosis: a critical appraisal.
1/2023The best and worst of times in therapy development for myasthenia gravis.
1/2023Presymptomatic amyotrophic lateral sclerosis: from characterization to prevention.
1/2023Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): a prospective, multicentre, open-label, non-randomised phase 1b/2a study.
1/2022Urinary neopterin: A novel biomarker of disease progression in amyotrophic lateral sclerosis.
1/2022Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.
1/2022Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
8/2021Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design.
1/2021Humoral response to neurofilaments and dipeptide repeats in ALS progression.
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Michael Benatar Research Topics

Disease

34Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
12/2023 - 04/2007
27Myasthenia Gravis
01/2024 - 07/2006
8Disease Progression
01/2023 - 05/2011
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 03/2013
3Infections
12/2023 - 05/2010
3Frontotemporal Dementia (Semantic Dementia)
01/2022 - 01/2012
3Asymptomatic Diseases
01/2022 - 01/2018
2Neoplasms (Cancer)
12/2023 - 01/2023
2Autoimmune Diseases (Autoimmune Disease)
01/2023 - 04/2015
2Spinal Cord Diseases
01/2023 - 02/2007
2Stroke (Strokes)
01/2023 - 02/2009
2Spinal Muscular Atrophy (Progressive Muscular Atrophy)
01/2022 - 02/2015
2Headache (Headaches)
01/2021 - 12/2017
2Thymoma (Thymic Carcinoma)
11/2020 - 12/2017
2Proteostasis Deficiencies
05/2013 - 03/2013
2Ischemic Stroke
02/2009 - 01/2008
1Prodromal Symptoms
01/2023
1Spastic Ataxia
01/2023
1Spinocerebellar Ataxias (Spinocerebellar Ataxia)
01/2023
1Rare Diseases (Rare Disease)
01/2023
1Alzheimer Disease (Alzheimer's Disease)
01/2022
1Parkinson Disease (Parkinson's Disease)
01/2022
1Inflammation (Inflammations)
08/2021
1Meningococcal Infections
01/2019
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
01/2019
1Fatigue
01/2018
1Thymus Neoplasms (Thymus Neoplasm)
12/2017
1Meningococcal Meningitis
12/2017
1Respiratory Tract Infections (Respiratory Tract Infection)
12/2017
1Respiratory Insufficiency (Respiratory Failure)
12/2016
1Guillain-Barre Syndrome
12/2016
1Autonomic Nervous System Diseases (Dysautonomia)
12/2016
1Vascular Diseases (Vascular Disease)
07/2015

Drug/Important Bio-Agent (IBA)

23Biomarkers (Surrogate Marker)IBA
12/2023 - 11/2010
12Cholinergic ReceptorsIBA
12/2023 - 07/2006
8Proteins (Proteins, Gene)FDA Link
08/2023 - 01/2012
5AntibodiesIBA
12/2023 - 07/2006
4glucose-mannose-glucoseIBA
01/2024 - 01/2019
4Rituximab (Mabthera)FDA Link
12/2021 - 09/2017
4Prednisone (Sone)FDA LinkGeneric
11/2020 - 03/2016
3Monoclonal AntibodiesIBA
01/2024 - 01/2021
3neonatal Fc receptorIBA
12/2023 - 01/2021
3Heat-Shock Proteins (Heat-Shock Protein)IBA
02/2020 - 01/2018
3Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2019 - 06/2007
3Edrophonium (Tensilon)FDA LinkGeneric
01/2019 - 07/2006
3Intravenous Immunoglobulins (IVIG)FDA Link
12/2017 - 10/2013
3SteroidsIBA
07/2016 - 10/2008
3Valosin Containing ProteinIBA
09/2012 - 12/2010
2RNA (Ribonucleic Acid)IBA
01/2023 - 01/2021
2AutoantibodiesIBA
01/2023 - 01/2020
2DNA (Deoxyribonucleic Acid)IBA
01/2023 - 04/2015
2Complement System Proteins (Complement)IBA
01/2023 - 12/2017
2Superoxide Dismutase-1IBA
01/2022 - 03/2013
2tofersenIBA
01/2022 - 01/2022
2Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA
01/2022 - 03/2017
2Antisense OligonucleotidesIBA
01/2022 - 01/2019
2margatoxinIBA
11/2020 - 01/2019
2Complement Inactivating AgentsIBA
01/2020 - 12/2017
2Adrenal Cortex Hormones (Corticosteroids)IBA
01/2019 - 12/2012
2Phosphotransferases (Kinase)IBA
01/2019 - 09/2017
2eculizumabFDA Link
01/2019 - 12/2017
2Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric
03/2016 - 02/2008
2Amino AcidsFDA Link
03/2013 - 12/2010
2Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
02/2010 - 02/2008
1bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA
01/2023
1N 30IBA
01/2023
1Chimeric Antigen ReceptorsIBA
01/2023
1Nitrous Oxide (Laughing Gas)IBA
01/2023
1B-Cell Maturation AntigenIBA
01/2023
1Amyloid (Amyloid Fibrils)IBA
01/2022
1NeopterinIBA
01/2022
1C-Reactive ProteinIBA
01/2022
1EdaravoneIBA
08/2021
1Antigen-Antibody Complex (Immune Complex)IBA
01/2021
1DipeptidesIBA
01/2021
1rozanolixizumabIBA
01/2021
1ChitinasesIBA
01/2020
1zilucoplanIBA
01/2020
1rho-Associated KinasesIBA
01/2019
1Peptides (Polypeptides)IBA
01/2019
1fasudil (AT 877)IBA
01/2019
1polyetheretherketoneIBA
01/2018
1arimoclomolIBA
01/2018
1Dihydrotachysterol (AT 10)IBA
09/2017
1Immunosuppressive Agents (Immunosuppressants)IBA
09/2017
1Methotrexate (Mexate)FDA LinkGeneric
07/2016
1Retinaldehyde (Retinal)IBA
07/2015
1Immunomodulating AgentsIBA
04/2015

Therapy/Procedure

24Therapeutics
01/2024 - 04/2007
6Thymectomy
11/2020 - 10/2013
5Activities of Daily Living (ADL)
01/2024 - 07/2016
2Plasma Exchange
12/2017 - 10/2013
1Traditional Medicine (Folk Remedies)
12/2023
1Injections
12/2023
1Plasmapheresis
12/2016
1Physical Therapy Modalities (Physical Therapy Technique)
12/2016
1Artificial Respiration (Mechanical Ventilation)
12/2016
1Immunotherapy
12/2016
1Noninvasive Ventilation
12/2016
1Denervation
02/2015